Foxo3^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Foxo3^tm1Rdp
• Name: forkhead box O3; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:2668317
• Synonyms: Foxo3^f, FoxO3^L
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84269
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which is the first coding exon, was flanked by a loxP-frt-neo-frt cassette in intron 1 and single loxP site in intron 2. Mice carrying this allele were bred with cre transgenic mice to generate Foxo3^tm1.1Rdp. (J:84269)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Granulosa Cell Tumor of the ovary J:232961.

References

• Original: J:84269 Castrillon DH, et al., Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003 Jul 11;301(5630):215-8
• All: 101 reference(s)