Foxo3^tm1.1Rdp
Targeted Allele Detail

Summary

• Symbol: Foxo3^tm1.1Rdp
• Name: forkhead box O3; targeted mutation 1.1, Ronald DePinho
• MGI ID: MGI:2668328
• Synonyms: Foxo3a^-
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^tm1.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84269
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region containing neo and exon 2 was excised from Foxo3^tm1Rdp via in vivo cre mediated recombination. Transcript was undetected by Northern blot analysis of homozygous mutant liver tissue. (J:84269)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Granulosa Cell Tumor of the ovary J:232961.

References

• Original: J:84269 Castrillon DH, et al., Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003 Jul 11;301(5630):215-8
• All: 46 reference(s)