Celsr1^Crsh
Chemically induced Allele Detail

Summary

• Symbol: Celsr1^Crsh
• Name: cadherin, EGF LAG seven-pass G-type receptor 1; crash
• MGI ID: MGI:2668337
• Synonyms: MUT1494
• Gene: Celsr1 Location: Chr15:85783130-85918404 bp, - strand Genetic Position: Chr15, 40.42 cM
• Alliance: Celsr1^Crsh page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A A-to-G point mutation at nucleotide 3126 was induced by ENU mutagenesis. The mutation results in an aspartate to glycine substitution at codon 1040, which lies within the eighth cadherin repeat of the extracellular domain. Western blot analysis indicates no difference in abundance of protein. (J:84285, J:216413)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Celsr1 Mutation: 146 strains or lines available

References

• Original: J:84285 Curtin JA, et al., Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 2003 Jul 1;13(13):1129-33
• All: 19 reference(s)