Prdx6^tm1Pgn
Targeted Allele Detail

Summary

• Symbol: Prdx6^tm1Pgn
• Name: peroxiredoxin 6; targeted mutation 1, Beverly Paigen
• MGI ID: MGI:2668338
• Synonyms: Prdx6^-
• Gene: Prdx6 Location: Chr1:161067682-161078780 bp, - strand Genetic Position: Chr1, 69.75 cM
• Alliance: Prdx6^tm1Pgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84376
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin drug resistance gene and a lacZ gene. RT-PCR demonstrated the absence of mRNA in the livers of homozygotes while the absence of protein was proven by Western blot and by immunohistochemistry. (J:84376)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Prdx6 Mutation: 52 strains or lines available

References

• Original: J:84376 Wang X, et al., Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003 Jul 4;278(27):25179-90
• All: 18 reference(s)