Map2k2^tm1Chrn
Targeted Allele Detail

Summary

• Symbol: Map2k2^tm1Chrn
• Name: mitogen-activated protein kinase kinase 2; targeted mutation 1, Jean Charron
• MGI ID: MGI:2668345
• Synonyms: MEK2^-
• Gene: Map2k2 Location: Chr10:80941749-80960531 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Map2k2^tm1Chrn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84382
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced sequences from exons 4, 5, and 6. This results in the loss of kinase subdomains VII and VIII. Western blot analysis of protein extracts from E11.5 embryos indicated that both full length and truncated protein were absent. (J:84382)

Expression

In Mice Carrying this Mutation:

14 assay results 5 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Map2k2^tm1Chrn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map2k2 Mutation: 37 strains or lines available

References

• Original: J:84382 Belanger LF, et al., Mek2 is dispensable for mouse growth and development. Mol Cell Biol. 2003 Jul;23(14):4778-87
• All: 35 reference(s)