Hip1^tm1Hay
Targeted Allele Detail

Summary

• Symbol: Hip1^tm1Hay
• Name: huntingtin interacting protein 1; targeted mutation 1, Michael Hayden
• MGI ID: MGI:2668380
• Synonyms: HIP1^-
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^tm1Hay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84278
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 8 was replaced with a cassette containing a splice acceptor site, an IRES, and sequence encoding a bifunctional lacZ-neomycin fusion protein. The insertion was designed to disrupt the expression of both isoforms that result from alternative splicing of the 5' region. Western blot analysis of the frontal cortex and striatum indicated an absence of normal protein in homozygous mutant mice. (J:84278)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:84278 Metzler M, et al., Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J. 2003 Jul 1;22(13):3254-66
• All: 4 reference(s)