Tnfsf14^tm1Ddy
Targeted Allele Detail

Summary

• Symbol: Tnfsf14^tm1Ddy
• Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Derek D Yang
• MGI ID: MGI:2668383
• Synonyms: LIGHT^-
• Gene: Tnfsf14 Location: Chr17:57496492-57501177 bp, - strand Genetic Position: Chr17, 29.71 cM, cytoband D-E1
• Alliance: Tnfsf14^tm1Ddy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84366
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3, which encode amino acids 1-98, were replaced with a PGK-neomycin cassette. Absence of mRNA was established by Northern blot analysis of RNA isolated from spleens of homozygotes. (J:84366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf14 Mutation: 27 strains or lines available

References

• Original: J:84366 Liu J, et al., LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function. Int Immunol. 2003 Jul;15(7):861-70
• All: 1 reference(s)