Bard1^tm1Thl
Targeted Allele Detail

Summary

• Symbol: Bard1^tm1Thl
• Name: BRCA1 associated RING domain 1; targeted mutation 1, Thomas Ludwig
• MGI ID: MGI:2668394
• Synonyms: Bard1^-
• Gene: Bard1 Location: Chr1:71066694-71142300 bp, - strand Genetic Position: Chr1, 35.67 cM
• Alliance: Bard1^tm1Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84329
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame in exon 1 (amino acids 1-46) was replaced with a hygromycin resistance-EGFP fusion gene. Western blot analysis of E9.5 homozygous embryos proved the absence of gene product. (J:84329)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bard1 Mutation: 55 strains or lines available

References

• Original: J:84329 McCarthy EE, et al., Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol. 2003 Jul;23(14):5056-63
• All: 2 reference(s)