Smad2^tm2.1Rob
Targeted Allele Detail

Summary

• Symbol: Smad2^tm2.1Rob
• Name: SMAD family member 2; targeted mutation 2.1, Elizabeth J Robertson
• MGI ID: MGI:2668416
• Synonyms: Smad2^CD
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm2.1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84300
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was excised via in vivo cre mediated recombination. Western blot analysis of homozygous mutant mice confirmed the absence of normal protein. (J:84300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:84300 Vincent SD, et al., Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003 Jul 1;17(13):1646-62
• All: 1 reference(s)