Prdx2^tm1Yu
Targeted Allele Detail

Summary

• Symbol: Prdx2^tm1Yu
• Name: peroxiredoxin 2; targeted mutation 1, Dae-Yeul Yu
• MGI ID: MGI:2668456
• Synonyms: Prdx2^-, Prx II^-
• Gene: Prdx2 Location: Chr8:85696251-85701440 bp, + strand Genetic Position: Chr8, 41.4 cM
• Alliance: Prdx2^tm1Yu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84271
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing exons 1 through 5 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of RBCs indicated an absence of protein in homozygous mutant mice. (J:84271)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdx2 Mutation: 22 strains or lines available

References

• Original: J:84271 Lee TH, et al., Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood. 2003 Jun 15;101(12):5033-8
• All: 39 reference(s)