Rln1^tm1Wint
Targeted Allele Detail

Summary

• Symbol: Rln1^tm1Wint
• Name: relaxin 1; targeted mutation 1, Marelyn Wintour
• MGI ID: MGI:2668458
• Synonyms: Rln^-, rlx-
• Gene: Rln1 Location: Chr19:29309155-29312070 bp, - strand Genetic Position: Chr19, 23.83 cM
• Alliance: Rln1^tm1Wint page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52024
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 750 bp fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 90 carboxy terminal amino acids of the 103 amino acids that make up the C peptide and 17 amino terminal amino acids of the 25 amino acids that comprise the A chain. Northern blot analysis of ovarian RNA indicated an absence of normal transcript in homozygous mutant females. (J:52024)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rln1 Mutation: 17 strains or lines available

References

• Original: J:52024 Zhao L, et al., Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology. 1999 Jan;140(1):445-53
• All: 27 reference(s)