Ilk^tm1Star
Targeted Allele Detail

Summary

• Symbol: Ilk^tm1Star
• Name: integrin linked kinase; targeted mutation 1, Rene St-Arnaud
• MGI ID: MGI:2668459
• Synonyms: ILK^fl, ILK^flox, ILK(lox), ilk^loxP
• Gene: Ilk Location: Chr7:105385799-105392132 bp, + strand Genetic Position: Chr7, 55.97 cM, cytoband E1
• Alliance: Ilk^tm1Star page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84273
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted downstream of exon 4 and exon 12 (along with a neomycin resistance gene cassette). (J:84273)

Disease models

Expression

In Mice Carrying this Mutation:	26 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ilk Mutation: 18 strains or lines available

References

• Original: J:84273 Terpstra L, et al., Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol. 2003 Jul 7;162(1):139-48
• All: 61 reference(s)