Serpini1^tm1Dpw
Targeted Allele Detail

Summary

• Symbol: Serpini1^tm1Dpw
• Name: serine (or cysteine) peptidase inhibitor, clade I, member 1; targeted mutation 1, David Paul Wolfer
• MGI ID: MGI:2668495
• Synonyms: Ns -
• Gene: Serpini1 Location: Chr3:75464800-75549830 bp, + strand Genetic Position: Chr3, 33.76 cM
• Alliance: Serpini1^tm1Dpw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84427
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 2. Western blot analysis demonstrated the absence of gene product in homozygotes. (J:84427)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpini1 Mutation: 29 strains or lines available

References

• Original: J:84427 Madani R, et al., Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol Cell Neurosci. 2003 Jul;23(3):473-94
• All: 6 reference(s)