Hprt1^tm6Detl
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm6Detl
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 6, Peter J Detloff
• MGI ID: MGI:2668521
• Synonyms: hprt^NosignalQ150
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm6Detl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84451
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Disruption caused by insertion of vector, Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a cassette containing a myc tag, and 150 CAG repeats encoding 150 glutamine residues. Neither a nuclear localization signal (NLS) nor a nuclear export signal (NES) was included in the targeting construct. (J:84451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:84451 Jackson WS, et al., Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet. 2003 Jul 1;12(13):1621-9
• All: 1 reference(s)