Grk1^tm1Citb
Targeted Allele Detail

Summary

• Symbol: Grk1^tm1Citb
• Name: G protein-coupled receptor kinase 1; targeted mutation 1, California Institute of Technology - Biology
• MGI ID: MGI:2668595
• Synonyms: GRK -, Grk1^tm1Mis, RK-
• Gene: Grk1 Location: Chr8:13455081-13471951 bp, + strand Genetic Position: Chr8, 5.93 cM, cytoband A2
• Alliance: Grk1^tm1Citb page

Altered morphology of Grk1^tm1Citb/Grk1^tm1Citb retina

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected in the retinas of homozygous mutant mice by Western blot analysis. (J:54021)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grk1 Mutation: 32 strains or lines available

References

• Original: J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
• All: 23 reference(s)