Neurod6^tm1(cre)Kan
Targeted Allele Detail

Summary

• Symbol: Neurod6^tm1(cre)Kan
• Name: neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:2668659
• Synonyms: Math2/Cre, Neurod6-cre, Neurod6/Cre, NexCre, NEX-Cre
• Gene: Neurod6 Location: Chr6:55654807-55658248 bp, - strand Genetic Position: Chr6, 27.53 cM
• Alliance: Neurod6^tm1(cre)Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62118
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Neurod6^tm1(cre)Kan expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurod6 (MGI:106593)

• Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing cre recombinase followed by a neomycin resistance gene in exon 2. The endogenous promoter drove expression of cre in the granule cells of the hippocampus. (J:62118, J:117061)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurod6 (mouse) Summary of all recombinase alleles driven by Neurod6. Comparative matrix view of recombinase activities Alliance mouse Neurod6 gene page

Disease models

Expression

In Mice Carrying this Mutation:

61 assay results 10 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod6 Mutation: 18 strains or lines available

References

• Original: J:62118 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci. 2000 May 15;20(10):3714-24
• All: 323 reference(s)