Myl7^tm1(cre)Krc
Targeted Allele Detail

Summary

• Symbol: Myl7^tm1(cre)Krc
• Name: myosin, light polypeptide 7, regulatory; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2668722
• Synonyms: Mlc2a^-, MLC2a-Cre
• Gene: Myl7 Location: Chr11:5846637-5848782 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Myl7^tm1(cre)Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84611
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Myl7^tm1(cre)Krc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myl7 (MGI:107495)

• Mutation details: Exons 1 through 7 were replaced with sequence encoding cre recombinase and neo. Protein was undetected by Western blot analysis of homozygous mutant embryos. Instead, Cre recombinase is expressed via the endogenous promoter. (J:87043)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myl7 (mouse) Summary of all recombinase alleles driven by Myl7. Alliance mouse Myl7 gene page

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myl7 Mutation: 7 strains or lines available

References

• Original: J:84611 Wegener JW, et al., cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res. 2002 Jan 11;90(1):18-20
• All: 16 reference(s)