Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:78169Two separate backcross populations were analyzed for loci associated with spontaneous activity. Parental strains NJL/Ms and KJR/Ms are hyperactive whereas parental strain BLG2/Ms is hypoactive. 93 polymorphic markers at an average spacing of 20 cM were screened in (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms and (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross populations. A locus reached peak significance in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population at D3Mit128 (83.5 cM, LOD=4.8) on mouse Chromosome 3 and was named Loco1. KJR/Ms-derived alleles appear to confer increased activity at this locus. A second locus mapped to mouse Chromosome 17 at D17Mit168 (23 cM, LOD=2.2) in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population and was named Loco2. This locus interacts epistatically with Loco1. KJR/Ms-derived alleles confer increased activity at Loco2 only when KJR/Ms alleles are also present at Loco1. Linkage analysis of the (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross population did not yield any QTLs. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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