Loco2^KJR/Ms
QTL Variant Detail

Summary

• QTL variant: Loco2^KJR/Ms
• Name: locomotor activity 2; KJR/Ms
• MGI ID: MGI:2669268
• QTL: Loco2 Location: Chr17:43884972-43885114 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 19.74 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: KJR/Ms

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele interacts with Loco1 to confer increased spontaneous activity compared to BLG2/Ms. (J:78169)

Notes

This locus interacts epistatically with Loco1. KJR/Ms-derived alleles confer increased activity at Loco2 only when KJR/Ms alleles are also present at Loco1.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78169

Two separate backcross populations were analyzed for loci associated with spontaneous activity. Parental strains NJL/Ms and KJR/Ms are hyperactive whereas parental strain BLG2/Ms is hypoactive. 93 polymorphic markers at an average spacing of 20 cM were screened in (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms and (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross populations.

A locus reached peak significance in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population at D3Mit128 (83.5 cM, LOD=4.8) on mouse Chromosome 3 and was named Loco1. KJR/Ms-derived alleles appear to confer increased activity at this locus.

A second locus mapped to mouse Chromosome 17 at D17Mit168 (23 cM, LOD=2.2) in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population and was named Loco2. This locus interacts epistatically with Loco1. KJR/Ms-derived alleles confer increased activity at Loco2 only when KJR/Ms alleles are also present at Loco1.

Linkage analysis of the (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross population did not yield any QTLs.

References

• Original: J:78169 Furuse T, et al., QTL analyses of spontaneous activity by using mouse strains from Mishima battery. Mamm Genome. 2002 Aug;13(8):411-5
• All: 1 reference(s)