Derms^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: Derms^BALB/cByJ
• Name: dermatitis susceptibility; BALB/cByJ
• MGI ID: MGI:2669293
• QTL: Derms Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to atopic dermatitis compared to C3H/HeJ and C57BL/6J. (J:80574)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80574

Linkage analysis was performed on 5 different populations of backcross animals using 243 polymorphic markers spanning 19 autosomes to identify QTLs associated with atopic dermatitis. The NOA strain develops ulcerative skin lesions and was crossed separately to each of the parental strains C57BL/6J, IQI, C3H/HeJ, DBA/2J, and BALB/cByJ. Backrosses were generated from these F1 animals. 559 backcross animals were examined and used for genotyping.

A significant locus (P<0.001) was detected on central mouse Chromosome 14 spanning a 17.5 cM interval and is designated Derms (dermatitis susceptibility). The Derms locus is flanked by markers D14Mit236 (32.5 cM) and D14Mit160 (40 cM).

References

• Original: J:80574 Natori K, et al., Mapping of a gene responsible for dermatitis in NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis. J Hum Genet. 1999;44(6):372-6
• All: 1 reference(s)