Ighg1^tm1Ksho
Targeted Allele Detail

Summary

• Symbol: Ighg1^tm1Ksho
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1, Tsuneyasu Kaisho
• MGI ID: MGI:2669500
• Synonyms: IgG1^{delta tail}
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^tm1Ksho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39568
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: This allele, which encodes a truncated protein capable of localizing to the membrane but lacking the cytoplasmic tail, was generated by homologous recombination of a targeting vector containing a nonsense mutation at the fourth codon of the cytoplasmic tail. In addition, single loxP sites were left flanking the exon encoding the transmembrane domain. (J:39568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 28 strains or lines available

References

• Original: J:39568 Kaisho T, et al., The roles of gamma1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science. 1997 Apr 18;276(5311):412-5
• All: 1 reference(s)