Srsf3^tm1Pjln
Targeted Allele Detail

Summary

• Symbol: Srsf3^tm1Pjln
• Name: serine and arginine-rich splicing factor 3; targeted mutation 1, Peter J Nielsen
• MGI ID: MGI:2669749
• Synonyms: p, SRp20^p
• Gene: Srsf3 Location: Chr17:29251634-29262346 bp, + strand Genetic Position: Chr17, 15.03 cM
• Alliance: Srsf3^tm1Pjln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted into intron 1, and a single loxP site was inserted into intron 3 by homologous recombination. RT-PCR analysis of RNA derived from homozygous mice demonstrated that the insertions had no effect on the normal expression of the gene. (J:57047)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	49 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf3 Mutation: 27 strains or lines available

References

• Original: J:57047 Jumaa H, et al., Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20. Curr Biol. 1999 Aug 26;9(16):899-902
• All: 6 reference(s)