Ltry^NZB/BlNJ
QTL Variant Detail

Summary

• QTL variant: Ltry^NZB/BlNJ
• Name: laterality; NZB/BlNJ
• MGI ID: MGI:2669867
• QTL: Ltry Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: NZB/BlNJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers low forepaw and hindpaw laterality values and high plasma lutenizing hormone concentration compared to C57BL/6ByJ. (J:82664)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82664

Genome scan was performed on 283 (C57BL/6ByJ x NZB/BlNJ)F2 animals using 67 microsatellite markers to identify QTLs associated with right-left paw laterality. Parental strain NZB/BlNJ is more ambidextrous in both the forepaw and hindpaw compared to parental strain C57BL/6ByJ.

A significant locus was identified on mouse Chromosome 4 and named Ltry (laterality). This locus is linked to forepaw laterality at 48 cM (LOD=5.6 at D4Mit205a), and is linked to hindpaw laterality at 49.7 cM (LOD=7.2 at D4Mit12).Ltry is also linked to plasma lutenizing hormone concentration (PLHC) at 48.8 cM with LOD=4.4. The QTL interval of Ltry spans approximately 30 cM - 63 cM. Low forepaw and hindpaw laterality values and high PLHC values are associated with the NZB/BlNJ-derived allele. A possible candidate gene for Ltry is the leptin receptor, Lepr. This gene maps to 46.7 cM on mouse Chromosome 4 and has been implicated in the gonadal steroid cycle.

References

• Original: J:82664 Roubertoux PL, et al., Analysis of quantitative trait Loci for behavioral laterality in mice. Genetics. 2003 Mar;163(3):1023-30
• All: 1 reference(s)