Pts^tm1Ich
Targeted Allele Detail

Summary

• Symbol: Pts^tm1Ich
• Name: 6-pyruvoyl-tetrahydropterin synthase; targeted mutation 1, Hiroshi Ichinose
• MGI ID: MGI:2669870
• Gene: Pts Location: Chr9:50432917-50440017 bp, - strand Genetic Position: Chr9, 27.73 cM
• Alliance: Pts^tm1Ich page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84764
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. Normal transcript was undetected by Northern blot analysis of homozygous mutant liver and brain tissue. (J:84764)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pts Mutation: 12 strains or lines available

References

• Original: J:84764 Sumi-Ichinose C, et al., Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem. 2001 Nov 2;276(44):41150-60
• All: 4 reference(s)