Btrc^tm1Kin
Targeted Allele Detail

Summary

• Symbol: Btrc^tm1Kin
• Name: beta-transducin repeat containing protein; targeted mutation 1, Kei-ichi Nakayama
• MGI ID: MGI:2669949
• Synonyms: Beta-TrCP1^-
• Gene: Btrc Location: Chr19:45352173-45518452 bp, + strand Genetic Position: Chr19, 38.75 cM, cytoband D1
• Alliance: Btrc^tm1Kin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA isolated from the testes of homozygous mutant mice. (J:84639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btrc Mutation: 46 strains or lines available

References

• Original: J:84639 Nakayama K, et al., Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8752-7
• All: 6 reference(s)