Ssrp1^tm1Rul
Targeted Allele Detail

Summary

• Symbol: Ssrp1^tm1Rul
• Name: structure specific recognition protein 1; targeted mutation 1, H Earl Ruley
• MGI ID: MGI:2669951
• Synonyms: Ssrp1^t
• Gene: Ssrp1 Location: Chr2:84867578-84877453 bp, + strand Genetic Position: Chr2, 49.45 cM
• Alliance: Ssrp1^tm1Rul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84557
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exons 14 to 17 were replaced with a PGK-neomycin cassette which thus deletes the HMG box domain as well as 87 C-terminal amino acids. Targeted ES cell clones produced only half as much protein as wild-type cells when assessed by Western blot. (J:84557)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssrp1 Mutation: 60 strains or lines available

References

• Original: J:84557 Cao S, et al., The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Mol Cell Biol. 2003 Aug;23(15):5301-7
• All: 1 reference(s)