Septin5^tm1Wtr
Targeted Allele Detail

Summary

• Symbol: Septin5^tm1Wtr
• Name: septin 5; targeted mutation 1, William S Trimble
• MGI ID: MGI:2669970
• Synonyms: CDCrel-1^-, CDCrel-1^Null
• Gene: Septin5 Location: Chr16:18440561-18448688 bp, - strand Genetic Position: Chr16, 11.53 cM
• Alliance: Septin5^tm1Wtr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84539
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4, 5, and part of 6 which together encode the P-loop consensus sequence were replaced with a PGK-neo cassette. Lack of protein product in brain tissues of homozygotes was confirmed immunologically using two different antibodies. (J:84539)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin5 Mutation: 27 strains or lines available

References

• Original: J:84539 Peng XR, et al., The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Mol Cell Biol. 2002 Jan;22(1):378-87
• All: 8 reference(s)