Ikzf1^plstc
Chemically induced Allele Detail

Summary

• Symbol: Ikzf1^plstc
• Name: IKAROS family zinc finger 1; plastic
• MGI ID: MGI:2669987
• Gene: Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
• Alliance: Ikzf1^plstc page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A transition point mutation (A to G) at position 572 resulted in a histidine to arginine missense mutation at codon 191 (H191R). The substitution disrupts the conserved Cys2His2 unit that tetrahedrally coordinates a zinc ion between the anitparallel beta sheet and alpha helix of the zinc finger. DNA binding is putatively disrupted by the interference of the tertiary structure of the N-terminal of zinc finger 3. A full length protein that assembles into higher order complexes is produced from this allele. (J:84569)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ikzf1 Mutation: 30 strains or lines available

References

• Original: J:84569 Papathanasiou P, et al., Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 2003 Jul;19(1):131-44
• All: 4 reference(s)