Rab3d^tm1Rja
Targeted Allele Detail

Summary

• Symbol: Rab3d^tm1Rja
• Name: RAB3D, member RAS oncogene family; targeted mutation 1, Reinhard Jahn
• MGI ID: MGI:2669989
• Synonyms: Rab3D-KO
• Gene: Rab3d Location: Chr9:21818787-21829488 bp, - strand Genetic Position: Chr9, 7.91 cM, cytoband A2-A3
• Alliance: Rab3d^tm1Rja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84542
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon was replaced with a neomycin resistance gene. Absence of gene protein was established by immunoblot analysis of pancreatic zymogen granules from homozygous mice. (J:84542)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab3d Mutation: 18 strains or lines available

References

• Original: J:84542 Riedel D, et al., Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol. 2002 Sep;22(18):6487-97
• All: 10 reference(s)