Berr2^WLA/Pas
QTL Variant Detail

Summary

• QTL variant: Berr2^WLA/Pas
• Name: berghei resistance locus 2; WLA/Pas
• MGI ID: MGI:2670003
• QTL: Berr2 Location: Chr11:115352609-115352758 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 80.84 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: WLA/Pas

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers resistance to Plasmomodium berghei-induced cerebral malaria compared to C57BL/6JRj. (J:78027)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78027

Genome scan was performed on 190 (WLA/Pas x C57BL/6JRj)F1 x C57BL/6JRj backcross animals using 132 microsatellite markers at an average spacing of 11 cM to identify QTLs associated with resistance to experimental cerebral malaria (ECM). Following infection with Plasmodium berghei, parental strain WLA/Pas is resistant to cerebral malaria but succumbs to hyperparasitemia after 11-25 days. Parental strain C57BL/6J is susceptible to cerebral malaria.

Significant linkage was detected on mouse Chromosome 1 and mouse Chromosome 11. These loci were named Berr1 (berghei resistance locus 1) and Berr2 (berghei resistance locus 2), respectively. These 2 loci jointly affect resistance to cerebral malaria.

Berr1 maps from 87.2 cM (D1Mit203) to 107.3 cM (D1Mit462) onmouse Chromosome 1 with peak linkage at 102 cM (D1Mit221, P=1.3 x 10-5). WLA/Pas-derived alleles appear to confer resistance to cerebral malaria at this locus. Tgfb2 maps to 101.5 cM on chromosome 1 and is a possible candidate gene for Berr1. Tgfb2 levels have been inversely correlated to the severity of malaria infections in mice.

Berr2 spans a 7 cM region on mouse Chromosome 11 with peak linkage at 75 cM (D11Mit338, P=4.8 x 10-5). WLA/Pas-derived alleles appear to confer resistance to cerebral malariaat this locus.

Suggestive linkage to ECM was detected on mouse Chromosome 14 at 25 cM (D14Mit113, P=1.4 x 10-3).

References

• Original: J:78027 Bagot S, et al., Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9919-23
• All: 1 reference(s)