Fen1tm1Klng
Targeted Allele Detail
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Symbol: |
Fen1tm1Klng |
Name: |
flap structure specific endonuclease 1; targeted mutation 1, Arne Klungland |
MGI ID: |
MGI:2670036 |
Synonyms: |
Fen1- |
Gene: |
Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
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Alliance: |
Fen1tm1Klng page
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Germline Transmission: |
Earliest citation of germline transmission:
J:84556
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2, containing the entire open reading frame, was replaced with a neomycin selection cassette inserted by homologous recombination.
(J:84556)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6 | | | | involves: C57BL/6 | |
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Phenotypes: |
Affected Systems |
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cellular
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√
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increased cellular sensitivity to gamma-irradiation
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√
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abnormal DNA repair
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√
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decreased DNA replication
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√
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embryo
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√
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abnormal blastocyst morphology
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√
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absent inner cell mass
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√
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inner cell mass degeneration
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√
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decreased trophoblast giant cell number
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√
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homeostasis/metabolism
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√
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abnormal DNA repair
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√
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decreased DNA replication
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√
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mortality/aging
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√
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embryonic lethality before implantation, complete penetrance
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√
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normal phenotype
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√
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no abnormal phenotype detected
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fen1 Mutation: |
32 strains or lines available
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Original: |
J:84556 Larsen E, et al., Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Mol Cell Biol. 2003 Aug;23(15):5346-53 |
All: |
2 reference(s) |
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