Mbl1^tm1.1Mnz
Targeted Allele Detail

Summary

• Symbol: Mbl1^tm1.1Mnz
• Name: mannose-binding lectin (protein A) 1; targeted mutation 1.1, Michel C Nussenzweig
• MGI ID: MGI:2670117
• Synonyms: MBL-A^-
• Gene: Mbl1 Location: Chr14:40873415-40881558 bp, + strand Genetic Position: Chr14, 22.36 cM
• Alliance: Mbl1^tm1.1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neomycin selection cassette that replaced all of exons 2 and 3 and a portion of exon 4 in Mbl1^tm1Mnz was excised from the germline via cre mediated recombination. Normal transcript was undetected by Northern blot analysis of total RNA obtained from thioglycolate-stimulated livers of homozygous mutant mice. (J:84540)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbl1 Mutation: 23 strains or lines available

References

• Original: J:84540 Lee SJ, et al., Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice. Mol Cell Biol. 2002 Dec;22(23):8199-203
• All: 1 reference(s)