Vti1b^tm1Gfvm
Targeted Allele Detail

Summary

• Symbol: Vti1b^tm1Gfvm
• Name: vesicle transport through interaction with t-SNAREs 1B; targeted mutation 1, Gabriele Fischer von Mollard
• MGI ID: MGI:2670119
• Synonyms: vti1b^-
• Gene: Vti1b Location: Chr12:79202791-79219428 bp, - strand Genetic Position: Chr12, 35.51 cM
• Alliance: Vti1b^tm1Gfvm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84574
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, which encodes the SNARE motif, was disrupted by the insertion of a neomycin selection cassette. Neither normal transcript nor normal protein was detected in homozygous mutant mice by Northern and Western blot analyses. (J:84574)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vti1b Mutation: 14 strains or lines available

References

• Original: J:84574 Atlashkin V, et al., Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol Cell Biol. 2003 Aug;23(15):5198-207
• All: 9 reference(s)