Wasf2^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Wasf2^tm1Fwa
• Name: WASP family, member 2; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2670143
• Synonyms: WAVE2^neo
• Gene: Wasf2 Location: Chr4:132857843-132927067 bp, + strand Genetic Position: Chr4, 66.22 cM
• Alliance: Wasf2^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84642
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment encompassing exons 3 through 7 was replaced with a cassette containing floxed neo followed by IRES-GFP. Northern and Western blot analyses of homozygous mutant ES cells indicated an absence of normal transcript and protein. (J:84642)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasf2 Mutation: 120 strains or lines available

References

• Original: J:84642 Yan C, et al., WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15;22(14):3602-12
• All: 1 reference(s)