Tg(Itga2b-cre)NE1/21Emam
Transgene Detail

Summary

• Symbol: Tg(Itga2b-cre)NE1/21Emam
• Name: transgene insertion NE1/21, Nikla R Emambokus
• MGI ID: MGI:2670207
• Synonyms: gpIIb-Cre
• Transgene: Tg(Itga2b-cre)NE1/21Emam Location: unknown
• Alliance: Tg(Itga2b-cre)NE1/21Emam page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Itga2b-cre)NE1/21Emam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Itga2b

• Mutation details: The transgenic construct was comprised of an integrin alpha 2b genomic fragment, including 2.5 kb of promoter through 2.8 kb of intron 1, adjoined to sequence encoding cre recombinase with a nuclear localization signal. The cassette containng NLS-cre also contained a splice acceptor site, IRES, and a polyadenylation signal. The integrin alpha 2b promoter drives expression of cre recombinase at the site of emergence of hematopoietic progenitors in the yolk sac, aorta-gonad-mesonephros region, and fetal liver. Founder mice contained between 2 and 5 copies of the transgene. (J:84564)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Itga2b (species not specified) Summary of all recombinase alleles driven by Itga2b. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:84564 Emambokus NR, et al., The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity. 2003 Jul;19(1):33-45
• All: 2 reference(s)