Itga2btm1(GFP/cre)Emam
Targeted Allele Detail
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Symbol: |
Itga2btm1(GFP/cre)Emam |
Name: |
integrin alpha 2b; targeted mutation 1, Nikla R Emambokus |
MGI ID: |
MGI:2670210 |
Synonyms: |
gpIIb-, gpIIbGFPCre |
Gene: |
Itga2b Location: Chr11:102344134-102360570 bp, - strand Genetic Position: Chr11, 66.29 cM
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Alliance: |
Itga2btm1(GFP/cre)Emam page
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Germline Transmission: |
Earliest citation of germline transmission:
J:84564
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Parent Cell Line: |
TL1/TL-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutation: |
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Insertion
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Itga2btm1(GFP/cre)Emam expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Itga2b (MGI:96601) |
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Mutation details: The endogenous locus was disrupted by homologous recombination of a targeting vector containing sequence encoding a GFP-cre fusion protein followed by an FRT-flanked PGK-neo cassette. While expression of cre recombinase was detected in (and limited to) the megakaryocyte lineage by Western blot analysis, GFP fluorescence was not observed. Endogenous protein was undetected by either flow cytometry or Western blot analysis of homozygous mutant bone marrow cells.
(J:84564)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Itga2b
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Itga2b Mutation: |
45 strains or lines available
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Original: |
J:84564 Emambokus NR, et al., The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity. 2003 Jul;19(1):33-45 |
All: |
14 reference(s) |
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