Ro60^tm1Woln
Targeted Allele Detail

Summary

• Symbol: Ro60^tm1Woln
• Name: Ro60, Y RNA binding protein; targeted mutation 1, Sandra L Wolin
• MGI ID: MGI:2670227
• Synonyms: Ro^-/-
• Gene: Ro60 Location: Chr1:143626528-143652794 bp, - strand Genetic Position: Chr1, 62.54 cM
• Alliance: Ro60^tm1Woln page

Glomerulonephritis in Ro60^tm1Woln/Ro60^tm1Woln mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84627
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetectable by Western blot analysis of homozygous mutant brain extracts. (J:84627)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ro60 Mutation: 39 strains or lines available

References

• Original: J:84627 Xue D, et al., A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7503-8
• All: 2 reference(s)