Rasgrf1^enu1H
Chemically induced Allele Detail

Summary

• Symbol: Rasgrf1^enu1H
• Name: RAS protein-specific guanine nucleotide-releasing factor 1; enu 1 Harwell
• MGI ID: MGI:2670335
• Synonyms: GENA53
• Gene: Rasgrf1 Location: Chr9:89791961-89909030 bp, + strand Genetic Position: Chr9, 47.31 cM
• Alliance: Rasgrf1^enu1H page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A transition point mutation (C to T) at nucleotide 2137 was induced by ENU mutagenesis. The mutation results in a nonsense mutation at codon 608, thereby precluding the translation of a full length protein. Protein was undetectable by Western blot analysis of homozygous mutant brain tissue. (J:84625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rasgrf1 Mutation: 66 strains or lines available

References

• Original: J:84625 Clapcott SJ, et al., Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation. Mamm Genome. 2003 Aug;14(8):495-505
• All: 4 reference(s)