Tnfrsf25^tm1Mjo
Targeted Allele Detail

Summary

• Symbol: Tnfrsf25^tm1Mjo
• Name: tumor necrosis factor receptor superfamily, member 25; targeted mutation 1, Michael J Owen
• MGI ID: MGI:2670362
• Synonyms: DR3-
• Gene: Tnfrsf25 Location: Chr4:152200391-152204576 bp, + strand Genetic Position: Chr4, 82.89 cM, cytoband E1
• Alliance: Tnfrsf25^tm1Mjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84536
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing the entire coding region was replaced with a cassette containing IRES-lacZ and floxed neo. The deleted region extended from 56 bp upstream of the start codon to 297 bp downstream of the polyadenylation site. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:84536)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf25 Mutation: 23 strains or lines available

References

• Original: J:84536 Wang EC, et al., DR3 regulates negative selection during thymocyte development. Mol Cell Biol. 2001 May;21(10):3451-61
• All: 19 reference(s)