About   Help   FAQ
Thratm3Jas
Targeted Allele Detail
Summary
Symbol: Thratm3Jas
Name: thyroid hormone receptor alpha; targeted mutation 1, Jacques Samarut
MGI ID: MGI:2670368
Synonyms: TRalpha7
Gene: Thra  Location: Chr11:98631539-98659832 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Alliance: Thratm3Jas page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84537
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA loxP flanked cassette containing neo and tk genes replaced a 257 bp fragment of intron 7, eliminating a portion of the internal promoter that drives expression of two short isoforms, TRdeltaalpha1 and TRdeltaalpha2. The floxed selection genes were excised prior to germline transmission. Whereas wild-type levels of transcript encoding the two longer isoforms, TRalpha1 and TRalpha2, were detected in homozygous mutant mice, the levels of transcript encoding the shorter isoforms were reduced. (J:84537)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  40 strains or lines available
References
Original:  J:84537 Plateroti M, et al., Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development. Mol Cell Biol. 2001 Jul;21(14):4761-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/05/2024
MGI 6.24
The Jackson Laboratory