Gnpat^tm1Just
Targeted Allele Detail

Summary

• Symbol: Gnpat^tm1Just
• Name: glyceronephosphate O-acyltransferase; targeted mutation 1, Wilhelm W Just
• MGI ID: MGI:2670461
• Synonyms: DAPAT^-
• Gene: Gnpat Location: Chr8:125589772-125616796 bp, + strand Genetic Position: Chr8, 72.81 cM
• Alliance: Gnpat^tm1Just page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84690
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 through 7 were replaced by a neomycin selection cassette. Protein was undetected by Western blot analysis of protein extracts obtained from the Harderian glands of homozygous mutant mice. (J:84690)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnpat Mutation: 43 strains or lines available

References

• Original: J:84690 Rodemer C, et al., Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet. 2003 Aug 1;12(15):1881-95
• All: 17 reference(s)