Prdx1^tm1Rave
Targeted Allele Detail

Summary

• Symbol: Prdx1^tm1Rave
• Name: peroxiredoxin 1; targeted mutation 1, Richard A Van Etten
• MGI ID: MGI:2670538
• Synonyms: Prdx1^-
• Gene: Prdx1 Location: Chr4:116542796-116557196 bp, + strand Genetic Position: Chr4, 53.28 cM
• Alliance: Prdx1^tm1Rave page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84677
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was disrupted by the insertion of a transposon containing a PGK-neo cassette inserted by homologous recombination. (J:84677)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prdx1^tm1Rave

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdx1 Mutation: 39 strains or lines available

References

• Original: J:84677 Neumann CA, et al., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 2003 Jul 31;424(6948):561-5
• All: 8 reference(s)