Ubash3b^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Ubash3b^tm1Jni
• Name: ubiquitin associated and SH3 domain containing, B; targeted mutation 1, James N Ihle
• MGI ID: MGI:2670555
• Synonyms: Elf1^tm1Jni, p70 deficient, Sts1-, TULA-2^-
• Gene: Ubash3b Location: Chr9:40922056-41069358 bp, - strand Genetic Position: Chr9, 21.84 cM
• Alliance: Ubash3b^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79606
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin resistance gene in the antisensense orientation. Northern blot analysis indicated a lack of transcript while the absence of protein was confirmed immunologically. (J:79606)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubash3b Mutation: 39 strains or lines available

References

• Original: J:79606 Carpino N, et al., Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol. 2002 Nov;22(21):7491-500
• All: 14 reference(s)