Glce^tm1Jpli
Targeted Allele Detail

Summary

• Symbol: Glce^tm1Jpli
• Name: glucuronyl C5-epimerase; targeted mutation 1, Jin-Ping Li
• MGI ID: MGI:2670565
• Synonyms: Glce^-, Hsepi^-
• Gene: Glce Location: Chr9:61964526-62029891 bp, - strand Genetic Position: Chr9, 33.56 cM, cytoband C-D
• Alliance: Glce^tm1Jpli page

Kidney, lung, eye, skeletal and tail abnormalities in E18.5 Glce^tm1Jpli/Glce^tm1Jpli mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84695
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 341 C-terminal amino acids. (J:84695)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glce Mutation: 30 strains or lines available

References

• Original: J:84695 Li JP, et al., Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality. J Biol Chem. 2003 Aug 1;278(31):28363-6
• All: 9 reference(s)