Ofca4^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Ofca4^DBA/2J
• Name: open field activity and conditioned avoidance 4; DBA/2J
• MGI ID: MGI:2670714
• QTL: Ofca4 Location: unknown Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82672

Genome scan at an average spacing of 20 cM - 30 cM was performed on 391 male (C57BL/6J x DBA/2J)F2 animals to detect QTLs associated with spatial learning. Animals were subjected to the Morris water maze test and scored for rates of spatial learning and t statistics for distance traveled and latency to reach the hidden platform. The animals were also evaluated for open field activity in a novel environment and conditioned avoidance.

QTLs associated with spatial learning were mapped to 46 cM on mouse Chromosome 4 (Splrn1) and to approximately 39 cM on mouse Chromosome 12 (Splrn2). Splrn1 reaches LOD=5.0 peak significance and spans 0 cM - 56 cM on mouse Chromosome 4. Splrn1 accounts for 3.4% of the phenotypic variance. Splrn2 reaches LOD=5.1 peak significance and spans 19 cM - 58 cM on mouse Chromosome 12. Splrn2 accounts for 2.9% of the phenotypic variance.

Four QTLs associated with open field activity in a novel environment were identified. Ofca1 mapped to 71 cM on mouse Chromosome 3 (LOD=3.8), Ofca2 mapped to 53 cM on mouse Chromosome 7 (LOD=5.0), Ofca3 mapped to 8 cM on mouse Chromosome 15 (LOD=4.0), and Ofca4 mapped to 8 cM on mouse Chromosome 19 (LOD=4.1). Ofca2, Ofca3, and Ofca4 also show linkage to conditioned avoidance.

Cdav, a QTL linked to conditioned avoidance, was identified at 87 cM on mouse Chromosome 1 (LOD=5.4).

References

• Original: J:82672 Steinberger D, et al., Genetic mapping of variation in spatial learning in the mouse. J Neurosci. 2003 Mar 15;23(6):2426-33
• All: 1 reference(s)