Cfid^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Cfid^C57BL/6J
• Name: cystic fibrosis intestinal distress; C57BL/6J
• MGI ID: MGI:2670718
• QTL: Cfid Location: Chr10:46720403-46720483 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 24.48 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased survival in male animals compared to BALB/cJ. (J:82609)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82609

Genome scan of 156 loci was performed on a population of (B6.129P2-Cftr^tm1Unc x BALB/cJ-Cftr^tm1Unc)F2 animals to identify cystic fibrosis (CF) modifying QTLs. Males of parental strain BALB/cJ-Cftr^tm1Unc exhibit increased post-weaning survival compared to males of parental strain B6.129P2-Cftr^tm1Unc. Female animals from either strain do not exhibit this survival difference.

A locus spanning a 25 cM interval on mouse Chromosome 10, Cfid, was identified in association with post-weaning survival andintestinal distress in male animals. Cfid exhibits peak linkage at D10Mit194 (29 cM) with P=1.2 x 10-4. BALB/cJ-derived alleles confer increased lethality and intestinal blockage at Cfid whereas C57BL/6J-derived alleles confer increased survival.

Loci associated with survival to weaning were identified on mouse Chromosomes 3, 5, and X. Cfsw1 mapped to 49.7 cM on mouse Chromosome 3 and is associated with survival to weaning in female animals. Cfsw1 exhibits peak linkage at D3Mit189 (P=1.7 x 10-4) with BALB/cJ-derived alleles conferring increased survival. Cfw2 mapped to 58 cM on mouse Chromosome 5 and is associated with survival to weaning in female animals. Cfw2 exhibits peak linkage at D5Mit239 (P=8 x 10-6) with BALB/cJ-derived alleles conferring increased survival. Cfsw3 mapped to 37 cM on mouse Chromosome X and is associated with survival to weaning in male animals. Cfw3 spans from 29 cM - 45 cM and exhibits peak linkage at DXMit16 (P=3.1 x 10-10) with C57BL/6J-derived alleles conferring increased survival.

References

• Original: J:82609 Haston CK, et al., Loci of intestinal distress in cystic fibrosis knockout mice. Physiol Genomics. 2003 Jan 15;12(2):79-84
• All: 2 reference(s)