Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:82609Genome scan of 156 loci was performed on a population of (B6.129P2-Cftrtm1Unc x BALB/cJ-Cftrtm1Unc)F2 animals to identify cystic fibrosis (CF) modifying QTLs. Males of parental strain BALB/cJ-Cftrtm1Unc exhibit increased post-weaning survival compared to males of parental strain B6.129P2-Cftrtm1Unc. Female animals from either strain do not exhibit this survival difference. A locus spanning a 25 cM interval on mouse Chromosome 10, Cfid, was identified in association with post-weaning survival andintestinal distress in male animals. Cfid exhibits peak linkage at D10Mit194 (29 cM) with P=1.2 x 10-4. BALB/cJ-derived alleles confer increased lethality and intestinal blockage at Cfid whereas C57BL/6J-derived alleles confer increased survival.Loci associated with survival to weaning were identified on mouse Chromosomes 3, 5, and X. Cfsw1 mapped to 49.7 cM on mouse Chromosome 3 and is associated with survival to weaning in female animals. Cfsw1 exhibits peak linkage at D3Mit189 (P=1.7 x 10-4) with BALB/cJ-derived alleles conferring increased survival. Cfw2 mapped to 58 cM on mouse Chromosome 5 and is associated with survival to weaning in female animals. Cfw2 exhibits peak linkage at D5Mit239 (P=8 x 10-6) with BALB/cJ-derived alleles conferring increased survival. Cfsw3 mapped to 37 cM on mouse Chromosome X and is associated with survival to weaning in male animals. Cfw3 spans from 29 cM - 45 cM and exhibits peak linkage at DXMit16 (P=3.1 x 10-10) with C57BL/6J-derived alleles conferring increased survival. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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