H2ax^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: H2ax^tm1Fwa
• Name: H2A.X variant histone; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:2670743
• Synonyms: H2AX^delta
• Gene: H2ax Location: Chr9:44246012-44247374 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: H2ax^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84879
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Endogenous sequence encompassing the promoter, single exon, and poly A site was floxed and subsequently excised via cre-mediated recombination in ES cells, leaving a single loxP site in place of the endogenous gene. (J:84909)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying H2ax^tm1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2ax Mutation: 7 strains or lines available

References

• Original: J:84879 Bassing CH, et al., Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 2003 Aug 8;114(3):359-70
• All: 17 reference(s)