Kmt2a^tm1Thr
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1Thr
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:2670764
• Synonyms: Mlox
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68500
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A loxP-hygromycin resistance gene was inserted into intron 10 (J:84518, initially reported as intron 8 in J:68500) via homologous recombination. The targeted intron corresponds with a breakpoint region identified in human leukemia patients with t(9;11)(p22;q23). (J:68500)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:68500 Collins EC, et al., Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 2000 Aug;1(2):127-32
• All: 5 reference(s)