Mllt3^tm2Thr
Targeted Allele Detail

Summary

• Symbol: Mllt3^tm2Thr
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3; targeted mutation 2, Terence H Rabbitts
• MGI ID: MGI:2670765
• Synonyms: Alox
• Gene: Mllt3 Location: Chr4:87688162-87951601 bp, - strand Genetic Position: Chr4, 41.06 cM
• Alliance: Mllt3^tm2Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68500
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Other
• Mutation details: A puromycin-loxP cassette was inserted into an intron corresponding to a breakpoint region identified in human leukemia patients with t(9;11)(p22;q23). (J:68500)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt3 Mutation: 31 strains or lines available

References

• Original: J:68500 Collins EC, et al., Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 2000 Aug;1(2):127-32
• All: 3 reference(s)